RNA in cancer

GJ Goodall; VO Wickramasinghe

Journal article

RNA in cancer

GJ Goodall, VO Wickramasinghe

Nature Reviews Cancer | NATURE PORTFOLIO | Published : 2021

DOI: 10.1038/s41568-020-00306-0

Abstract

While the processing of mRNA is essential for gene expression, recent findings have highlighted that RNA processing is systematically altered in cancer. Mutations in RNA splicing factor genes and the shortening of 3′ untranslated regions are widely observed. Moreover, evidence is accumulating that other types of RNAs, including circular RNAs, can contribute to tumorigenesis. In this Review, we highlight how altered processing or activity of coding and non-coding RNAs contributes to cancer. We introduce the regulation of gene expression by coding and non-coding RNA and discuss both established roles (microRNAs and long non-coding RNAs) and emerging roles (selective mRNA processing and circula..

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University of Melbourne Researchers

Vihandha Wickramasinghe Author

Related Projects (1)

MECHANISMS OF REGULATING GENE EXPRESSION VIA SELECTIVE MRNA TRANSPORT

A critical step in the gene expression pathway that is altered in cancer is nuclear export of mRNA. We have demonstrated that mRNA export is..

Grants

Awarded by Victorian Cancer Agency

Funding Acknowledgements

The authors thank W. Filipowicz and P. Gregory for critically reading the manuscript. They gratefully acknowledge funding from the Australian National Health and Medical Research Council (GNT1127745 to V.O.W, and GNT1126711 and research fellowship GNT1118170 to GJG). V.O.W. is supported by an innovation fellowship from veski and a mid-career fellowship from the Victorian Cancer Agency.